IMU Discussion

[Fact Finder]

ASX Announcement
IMUGENE RECEIVES ETHICS APPROVAL TO START PHASE 2 nextHERIZON CLINICAL TRIAL OF CANCER IMMUNOTHERAPY HER-VAXX
_______________________________________________________________________________________
SYDNEY, Australia, 10 May 2022: Imugene Limited (ASX:IMU), a clinical stage immuno-oncology company, today announced it has received Human Research Ethics Committee (HREC) approval to commence a Phase 2 clinical trial of its immunotherapy candidate, HER-Vaxx in Australia.
Ethics approval is confirmation Imugene has completed all the necessary pre-clinical safety and efficacy testing of HER-Vaxx required to commence its nextHERIZON clinical trial in Australia.
nextHERIZON is an open-label, multi-center, signal generating, Phase 2 clinical trial designed to assess the safety and efficacy of HER-vaxx in combination with chemotherapy or pembrolizumab in patients with metastatic HER-2/neu over-expressing gastric or gastroesophageal junction adenocarcinomas who have previously progressed on trastuzumab. The study’s primary endpoints are safety and response rate. Secondary endpoints include duration of response, progression free survival, overall survival, and biomarker evaluation.
The Australian component of the Phase 2 trial will be conducted under Australia’s Clinical Trials Notification (CTN) Scheme meaning Imugene will notify the Therapeutic Goods Administration (TGA) of HREC approval and complete local site initiation activities. The first hospital to receive ethics approval is the Queen Elizabeth Hospital, Adelaide Australia under the direction of Principal Investigator Dr Tim Price. Additional clinical sites will be opened in Australia, and also in the US under Food and Drug Administration (FDA) investigational new drug (IND) approval in December 2021.
Imugene MD & CEO Leslie Chong said “The start of our Australian study is a significant milestone for Imugene and clinicians treating Australians faced with the challenge of HER-2+ gastric cancer and we look forward to further evaluating HER-Vaxx in combination with pembrolizumab in a relapsed/refractory metastatic setting.”
Full study details can also be found on clinical trials.gov under study ID: NCT05311176

 

[TechGirl]

 

[TechGirl]

Great new interview with Leslie & our main man Mr Yuman Fong

 

[Slymeat]

Imugene have released an easy to understand, and short, video explaining how their CHECKvacc oncolytic virus works to kill cancer cells.

This may be useful to share with friends and relatives who don't understand what Imugene is trying to achieve. It's only 2min 20sec long

CHECKvacc: Imugene's Enhanced Tumour Killing Technology

 

[Slymeat]

New Analyst Coverage: $0.50 price target

Noble Life Science Partners

"The start of the CF-hNIS trial in solid tumors is another milestone for the company's three technology platforms, with ASCO data from PD1-Vaxx and HER-Vaxx supporting our expectations for those trials. We are reiterating our Outperform rating and price target of $0.50 (USD) per share."

Not 100% independent, but good publicity none-the-less.

 

[Slymeat]

Medical News Today have written an in-depth article on VAXINIA.

Imugene's CEO Leslie Chong told Medical News Today that:

“we are keen to revolutionize cancer therapy, and no longer are we satisfied with incremental improvements in survival, we want to cure patients. By making cancer into one disease and having a targeted agent to obliterate it, that’s the holy grail of cancer therapeutics!”

The article briefly explains how oncolytic viruses work, talks specifically about Vaxinia, and the design of the clinical trial. It has lots of links to medical journals fro those interested in learning more.

For me, it's just nice to see the news getting spread far and wide. Especially when Leslie is openly stating her goal to completely cure patients.

I feel that good things are happening!

Cancer-killing virus injected into human for the first time in new clinical trial​

 

[Slymeat]

For anyone wondering whether or not Imugene is on the right path, the following is for you.

Do yourself a favour and watch the following YouTube clip. It will help you understand cancer and how Immunotherapy, assisted by oncolytic viruses (such as those developed by Imugene), IS the correct approach to help eradicate cancer.

I have already teed it up to start at the appropriate location.

Dr Jason Fung - The Cancer Paradym

Some background:

Dr Jason Fung is a nephrologist—he is a specialist in kidney disease and has written books on fasting, cancer, and diabetics. He simply knows his shit.

His discussion on cancer was completely eye opening for me. He argues from the fact that cancer cells are merely an adoration of normal cells where recent evolution changes have been striped away, leaving them in a more primitive state. They are more like single cell organisms. The problem with single-cell organisms is that they are pre-programmed to not cooperate with other cells and rather to do anything to survive. The immune system recognises this aberrant behaviour, and usually destroys them. But the cancer cells have tricks to disguise themselves and trick the immune system into leaving them alone. Hence the role of immunotherapy, and oncolytic viruses such as Imugene’s CF33 to tag the cancer cells to help the immune system find them.

The above is a gross simplification. Watch the video (about 15 minutes on cancer) and you will hear an expert in the field discuss it better than I have.

And for anyone who has ever struggled with weight, and traditional diets, watch the full YouTube clip to have your mind blown by how wrong the story of weight loss is that we have all been fed. This should awaken your thoughts to the concept that fasting is beneficial.

 

[Fact Finder]

Great news today. Congratulations to IMU and all those who agreed to participate in the trials.

My opinion only DYOR
FF

AKIDA BALLISTA

 

[Fact Finder]

Great news today. Congratulations to IMU and all those who agreed to participate in the trials.

My opinion only DYOR
FF

AKIDA BALLISTA

Just confirming there is an IMU webinar at 11am today should be a must watch as Leslie Chong has the lead researchers on trial with her. This is the link:

https://imugene.us7.list-manage.com...31936a9627acb6427c&id=b839fdb611&e=59208d2c1a

My opinion only DYOR
FF

AKIDA BALLISTA

 

[Fact Finder]

Imagine how much better the results may be when Her-Vaxx is used early stage before immune systems are compromised by chemo and radiation:

“The longest HER-Vaxx treated patients remain alive 2.5 years (with one patient approaching 3 years) after starting therapy. It is noteworthy that these patients generated the strongest anti-Her-2 antibody levels from their dosing schedule on HER-Vaxx”

Remember these were 4th stage terminal patients who had been treated with everything known to man before IMU gave them Her-Vaxx.

My opinion only DYOR
FF

AKIDA BALLISTA

 

[Slymeat]

I particularly liked the positivity displayed by the doctor, involved in the trial, who was invited to attend.

When asked how easy it was to administer this drug compared to other drugs for treatment of similar patients. He could hardly hold himself back and said something along the lines of:

This drug is no different to administering a vaccine jab. The alternative treatments require multiple visits to hospital, infusion of drugs over a few hours, a lengthy hospital stay to monitor cardiac side effects, and a lot of resources. This treatment is more cost effective and allows me to treat many more patients in the same time.

What a MASSIVE positive endorsement.

And how excited did Leslie look (the CEO). As a major shareholder, these results had been withheld from her until just before release. Her smile was amazing.

Now they have the go ahead with 100ug in subsequent trials. For this, Leslie let out that she expects even better results.

WOW!

 

[Fact Finder]

I particularly liked the positivity displayed by the doctor, involved in the trial, who was invited to attend.

When asked how easy it was to administer this drug compared to other drugs for treatment of similar patients. He could hardly hold himself back and said something along the lines of:

This drug is no different to administering a vaccine jab. The alternative treatments require multiple visits to hospital, infusion of drugs over a few hours, a lengthy hospital stay to monitor cardiac side effects, and a lot of resources. This treatment is more cost effective and allows me to treat many more patients in the same time.

What a MASSIVE positive endorsement.

And how excited did Leslie look (the CEO). As a major shareholder, these results had been withheld from her until just before release. Her smile was amazing.

Now they have the go ahead with 100ug in subsequent trials. For this, Leslie let out that she expects even better results.

WOW!

Just so exciting for all those working in the gastric cancer space across China, India and the rest of Asia where this disease proliferates.

The ease of treatment for the good Doctor means one very important thing he can see many more patient s in a day at a much lower cost.

As has been said the share price does what it does but hearing the excitement and joy in the Doctors voice was priceless.

My opinion only DYOR
FF

 

[Slymeat]

Could the Brainchip share price respond similarly to how the market has jumped back on board Imugene to just one positive announcement?

I do hope so!

But I am also aware they are VERY different companies and VERY different circumstances.

Today's Imugene announcement goes a long way to proving it is both safe and effective in humans!

Oh the wheels of medical trials turn ever so slowly.

 

[Fact Finder]

Could the Brainchip share price respond similarly to how the market has jumped back on board Imugene to just one positive announcement?

I do hope so!

But I am also aware they are VERY different companies and VERY different circumstances.

Today's Imugene announcement goes a long way to proving it is both safe and effective in humans!

Oh the wheels of medical trials turn ever so slowly.

Different markets true but both are looking for signals that risk has been reduced.

To the extent that both are the same today's IMU announcement is a confirmation that the technology works and that an industry player being the Doctor at the coal face can see a place for the proven technology in his market place and the advantages it will bring. The Mercedes Benz reveal and statements were of the same kind. They validated the technology and stated there was a place for it in an electric vehicle and the advantages it brings.

Proof of concept and confirmation of market are powerful where any investment is concerned.

Whenever I need patience in the biotech space I remember the Thalidomide babies and what horrors a drug treatment that is not safe and properly tested can visit on the innocent.

My opinion only DYOR
FF

 

[alwaysgreen]

Imagine how much better the results may be when Her-Vaxx is used early stage before immune systems are compromised by chemo and radiation:

“The longest HER-Vaxx treated patients remain alive 2.5 years (with one patient approaching 3 years) after starting therapy. It is noteworthy that these patients generated the strongest anti-Her-2 antibody levels from their dosing schedule on HER-Vaxx”

Remember these were 4th stage terminal patients who had been treated with everything known to man before IMU gave them Her-Vaxx.

My opinion only DYOR
FF

AKIDA BALLISTA

And not at full dosage. How much will the results improve once a full dosage is administered. Sky is the limit. What a great company.

 

[jeff2151]

Could the Brainchip share price respond similarly to how the market has jumped back on board Imugene to just one positive announcement?

I do hope so!

But I am also aware they are VERY different companies and VERY different circumstances.

Today's Imugene announcement goes a long way to proving it is both safe and effective in humans!

Oh the wheels of medical trials turn ever so slowly.

Yes, the wheels turn very slowly in most of the small caps - even the best ones, like IMU, BRN, WBT. But as we keep saying, patience will be rewarded. And, as a bonus, in the case of IMU many, many patients and their loved ones will be rewarded,
I'm just back from a check-up with my ophthalmologist - all good news from him! - and was delighted to see that IMU was finally able to release some results. And, as expected, the news was great and as I type tis the shares are up nearly 50%. The smile on the faces as they answered shareholders' questions told me they were thinking "You ain't seen nothing yet!".
The results released today were from a trial designed to test the safety of one of IMU's many cancer treatments. The trial participants were all close to death. With some of them now leading normal lives, up to three years after being treated, I guess you could say it seems pretty safe!!
It is not unreasonable to expect that: 1. The other IMU drugs, that are "the same only different" will also prove completely safe, and quite possibly effective; 2. The next testing phase with this drug, being at a clinically significant strength, will lead to more significant responses,
What wonderful news this is for all present and future cancer sufferers! Sure feels good to be a shareholder!
Jeff

 

[Fact Finder]

And not at full dosage. How much will the results improve once a full dosage is administered. Sky is the limit. What a great company.

I think it is the New Horizon trial but the names get very confusing but it is the one where they will be treating the early stage victims of gastric cancer is the one that could blow the socks off in this area.

The full approved dosage as you point out and reasonably strong and functional immune systems to activate against the disease should be a winner.

We lost an aunt in the UK to gastric cancer during the Covid lock down. She was diagnosed late stage and treatment was never thought likely to help. Most gastric cancer is found late seldom early.

If Brainchip and NaNose can get the VOC cancer detection up and running so early diagnosis can be achieved routinely and IMU can get the results we expect this will truly be wonderous. Gastric cancer is an awful disease.

My opinion only DYOR
FF

 

[alwaysgreen]

I think it is the New Horizon trial but the names get very confusing but it is the one where they will be treating the early stage victims of gastric cancer is the one that could blow the socks off in this area.

The full approved dosage as you point out and reasonably strong and functional immune systems to activate against the disease should be a winner.

We lost an aunt in the UK to gastric cancer during the Covid lock down. She was diagnosed late stage and treatment was never thought likely to help. Most gastric cancer is found late seldom early.

If Brainchip and NaNose can get the VOC cancer detection up and running so early diagnosis can be achieved routinely and IMU can get the results we expect this will truly be wonderous. Gastric cancer is an awful disease.

My opinion only DYOR
FF

Sorry for your loss mate. Agree, it is an insidious disease.

 

[Terroni2105]

Fantastic news today.
Excellent short interview with Leslie Chong today.

Imugene releases final data from Phase 2 HER-Vaxx study

Imugene Ltd (ASX:IMU, OTC:IUGNF)'s Leslie Chong joins Proactive's Andrew Scott to outline the final overall survival data from the company's Phase 2...

www.proactiveinvestors.com.au

 

[Terroni2105]